The treatment of warts was often subject of research in history. Many methods and the application of different, sometimes exotic materials are described, which led to a partial disappearance of tough warts. The large number of therapies used is probably a reflection of the inadequacy of these methods, or simply a result of the fact that warts disappear without any type of treatment. Solutions were sought in psychological approaches or in giving medication. In the first case, they used magic, psychological treatment or methods resting on suggestion. As medication was used, among others: arsenic, quicksilver, nitric acid, ethyl chloride, carbon dioxide, sodium bisulfite, calcium phosphate, raw cow's milk, bismuth, magnesium sulfate, sulpharsphenamine and nitric salicylic. Further, radium, X-ray therapy, electrolysis, autohemotherapy, immunotherapy and ultrasound therapy were applied. The common wart, which is caused by infection with human papilloma viruses (HPV), gives increasing problems. Formerly warts on hands and feet were easily cured with treatment forms such as liquid nitrogen, electro desiccation or cut outs.
Nowadays, however, we see more and more HPV types who appear to be resistant to the usual methods of treatment. In addition, regularly immune deficiency as a result of treatment with immunosuppressants or diseases occurs. The failure of the conventional treatment made doctors look for alternatives. For this reason, a wide variety of methods is tested. Various types of laser-therapy and electro-coagulation, dephencyprone, vitamin A, glutaraldehyde, podophyllin, cryotherapy, 5-fluorouracil, radiation therapy or interferon, the cover with a banana peel, intralesional dosing of bleomycin per injection and plasters with bleomycin have been studied for applicability in the fight against stubborn warts.
Diverse therapie resistente wratten voor behandeling.
The dosing of bleomycin by means of dermatography appears to be very effective in this group of patients.
This method, dermatography, makes it possible to apply bleomycin in the skin at a depth that can be determined accurately, with an even distribution over the entire area that has to be treated. The adverse reactions reported by others on intralesional use of bleomycin, such as nail loss, Raynaud's phenomenon and bruising did not occur. Therefore the reliability of this needle technique is fully supported. Unlike previous studies, the absence of necrosis due to bruising seems to indicate that this complication is not inevitable in the fight against warts. The therapy-resistant warts that were selected for treatment were warts that gave patients the most discomfort, such as warts on feet, heels and hands. It was found that warts on other body parts that were not treated, also spontaneously disappeared. Especially in patients taking immunosuppressants such as prednisone or cyclosporine. The soft skin damage that is caused by this specific method of treatment immediately put the Langerhans cells into operation. This leads to a very rapid cellular immune response of the body.
Mosaic wratten voor en na 3 behandelingen met Bleomycine 0.3 ml oplossing.
Wratten hielgewricht onmogelijk om nog te lopen, voor en na 3 behandelingen met Bleomycine 0.3 ml oplossing.
This skin damage is very important because this mobilizes all immune cells and the mechanism immediately. It ultimately provides a great and powerful immune response. Also, the body that is treated multiple times (2 -3 times) with an active substance (such as, in this case, bleomycin) is able to create antibodies itself to go for the complete neutralization of the HPV virus throughout the body. The results have shown that this very low dosage is effective.(With 0.3 - 1.0 ml bleomycin solution, with an average concentration of 0.5 mg / ml of bleomycin, the concentration may be increased to 1 mg / ml due to a lack of response to the initial concentration). The relatively low level of pain when treated with dermatography, both during and after the treatments, is due to the rapid repeated perforation of the skin by the needles. Taking blood samples before, during and after treatment show no adverse effects. These treatments can obviously only take place in a hospital and not in a clinic.
Patiënt met honderden wratten over het gehele lichaam voor en na 5 behandelingen met bleomycine 1.0 ml oplossing en follow-up van 4 maanden.